Weniger Asthma durch spätere Impfungen

Eine neue Untersuchung von McDonald und anderen kam zu dem Ergebnis, dass das Risiko an Asthma zu erkranken, um die Hälfte vermindert wird, wenn die Impfung(Tetanus, Diphtherie, Keuchhusten)  um 2 Monate nach hinten verschoben wird.

Frühe Impfungen werden als Auslöser für Asthma angesehen, da sie das Immunsystem in eine bestimmte Richtung hin verändern können (TH1--> TH2 Shift), welche allergische Erkrankungen, wie auch Asthma auslösen kann.

Delay in diphtheria, pertussis, tetanus vaccination is
associated with a reduced risk of childhood Asthma
Kara L. McDonald, MSc,a Shamima I. Huq, BSc,b,d,e Lisa M. Lix, PhD,a,d Allan B. Becker, MD, FRCPC,c
and Anita L. Kozyrskyj, PhDa,b,c,d,e Winnipeg, Manitoba, Canada
Background: Early childhood immunizations have been
viewed as promoters of Asthma development by stimulating a
TH2-type immune response or decreasing microbial
pressure, which shifts the balance between TH1 and TH2
immunity.
Objective: Differing time schedules for childhood
immunizations may explain the discrepant findings of an
association with Asthma reported in observational studies. This
research was undertaken to determine whether timing of
diphtheria, pertussis, tetanus (DPT) immunization has an effect
on the development of childhood Asthma by age 7 years.
Methods: This was a retrospective longitudinal study of a cohort
of children born in Manitoba in 1995. The complete
immunization and health care records of cohort children from
birth until age 7 years were available for analysis. The adjusted
odds ratio for Asthma at age 7 years according to timing of DPT
immunization was computed from multivariable logistic
regression.
Results: Among 11, 531 children who received at least 4 doses of
DPT, the risk of Asthma was reduced to ½ in children whose first
dose of DPT was delayed by more than 2 months. The likelihood
of Asthma in children with delays in all 3 doses was 0.39 (95%
CI, 0.18-0.86).
Conclusion: We found a negative association between delay in
administration of the first dose of whole-cell DPT immunization
in childhood and the development of Asthma; the association
was greater with delays in all of the first 3 doses. The
mechanism for this phenomenon requires further research.
(J Allergy Clin Immunol 2008;121:626-31.)